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Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy

Organization of the Research Report if you doing Review article:
Introduction (short)
Conclusions and Summary (brief)
References (not required only if you used any)

Answer the following questions:

A) How does cancer develop in an immunocompetent host?

B) Why is the effect of cancer immunotherapy many times limited?

C) What are Immune checkpoint molecules and how they work?

D) How does the Immune Checkpoint Blockade Therapy using Anti-PD-L1 Ab works? Does it work for all cancers?